Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Transmission. Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
Molecular and Structural Analysis of Specific Mutations from Saudi Isolates of SARS-CoV-2 RNA-Dependent RNA Polymerase and their Implications on Protein Structure and Drug-Protein BindingArticle Published on 2022-10-012022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Affect approaches binding energy caused collected conformational Coronavirus-2 COVID-19 COVID-19 pandemic develop effort element health system information Interaction isolate molecular Molecular dynamics simulation morbidity and mortality mutant RdRp mutants Mutation mutations mutations. Pandemics Protein protein stability RdRP Remdesivir RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 RdRp sequence SARS-CoV2 Saudi Arabia secondary structure significant level Specific Structure therapeutic variety virus wild type wild-type Wuhan, China [DOI] 10.3390/molecules27196475 PMC 바로가기
A BioID-Derived Proximity Interactome for SARS-CoV-2 ProteinsSARS-CoV-2 단백질에 대한 BioID 파생 근접 상호작용체Article Published on 2022-03-152022-09-11 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis antiviral therapies antivirals assist association BioID caused Cell cells cellular cellular pathway COVID-19 COVID-19 pandemic drug library enrichment analysis expressing Follow-up Functional enrichment analyses Health Host host cell host cells human lung identify Interaction interactome labeling lung cancer mechanism Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis Protein Proteins proteome proteomic proximity labeling. reported responsible SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 proteins SARS-CoV-2 viral the SARS-CoV-2 TurboID understanding valuable resource Viral proteins was used website [DOI] 10.3390/v14030611 PMC 바로가기 [Article Type] Article
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISHCoronaFISH를 사용한 SARS-CoV-2 RNA의 민감한 시각화Research Article Published on 2022-01-072022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation African green monkey caused cell lines complement coronavirus COVID-19 COVID-19 pandemic Critical diagnostics Drug screening electron microscopy green monkey human cell lines infected cell infected cells Infection initial linear lung tissue Microscopy nasal swabs oligonucleotide sequences pathophysiology Patient positive positive-sense single-stranded RNA probe probes protocol Replication required Research respiratory RNA RNA virus SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 RNA Screen sensitive severe acute respiratory syndrome Coronavirus source code synthesis Template therapeutic molecules tissue Transcription Viral viral replication Viral RNA virus vRNA [DOI] 10.26508/lsa.202101124 PMC 바로가기 [Article Type] Research Article
Assessing the risk of vaccine-driven virulence evolution in SARS-CoV-2Organismal and Evolutionary Biology Published on 2022-01-052022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Alter Assessing booster doses COVID-19 COVID-19 vaccine disease disease severity Effect Efficacy Evidence Evolution Evolution of SARS-CoV-2 exacerbate Immunity immunized increases in indicate individual Infection outcome Population provide risk robust SARS-CoV-2 SARS-CoV-2 biology sustained Transmission unlikely vaccinal vaccination rate vaccination rates Vaccine virulence virulence evolution [DOI] 10.1098/rsos.211021 PMC 바로가기 [Article Type] Organismal and Evolutionary Biology
Development of a Single-Cycle Infectious SARS-CoV-2 Virus Replicon Particle System for Use in Biosafety Level 2 LaboratoriesVirus-Cell Interactions Published on 2021-12-012022-10-30 Journal: Journal of Virology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 3CL activity acute respiratory syndrome addition anti-CoV drug antiviral drug antiviral drugs biosafety Biosafety Level 2 Biosafety Level 3 BSL2 BSL3 Cell cell types conditions contagious coronavirus CoV decrease deleting development drug dose ENCODE expressing expression fluorescent GFP glycoprotein glycoprotein G host cells Immunity Infection Laboratory lack murine mutant neutralized Particle platform Protease inhibitor Protein Remdesivir replication of SARS-CoV-2 replicon reporter reporters Research robust S gene SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 research SARS-CoV-2 virus Scientific community serum spike gene Support System Treatment Vaccine variety vesicular stomatitis virus viral envelope viral genome viral glycoproteins VSV [DOI] 10.1128/jvi.01837-21 PMC 바로가기 [Article Type] Virus-Cell Interactions
The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 ReplicationNF-κB 전사 발자국은 SARS-CoV-2 복제에 필수적입니다Article Published on 2021-11-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] absence Activation analysis Antiviral approach canonical caused characterized COVID-19 COVID-19 pandemic cytokine production Defense dependency develop Disruption driving effective antiviral treatment effective vaccine Effective vaccines effort Essential etiological agent Factor Footprint IFN-I IFN-I response in vitro infected cells inhibitors molecular basis morbidity Mortality new SARS-CoV-2 NF-κB NF-κB signaling P50 p65 product reduced rescued robust SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 replication SARS-CoV-2. screenings selective single-cell These data transcription factor transcription factors transcriptomic type I interferon variant viral replication virus replication [DOI] 10.1128/JVI.01257-21 PMC 바로가기 [Article Type] Article
The Omic Insights on Unfolding Saga of COVID-19COVID-19의 전개에 대한 Omic InsightsReview Published on 2021-10-202022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy artificial intelligence carried co-morbidities coronavirus coronavirus disease COVID-19 diagnostics drug effective Epidemiology host-pathogen interactions hosts insight machine learning management Novel coronavirus ORFs pandemic Pandemics Research respiratory SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus Symptoms the disease Treatment Vaccine variants Viral virus [DOI] 10.3389/fimmu.2021.724914 PMC 바로가기 [Article Type] Review
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article